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Abstract #1544

3D Ultrashort Echo Time MR Fingerprinting (3D UTE-MRF) for Whole Brain Myelin Imaging

Zihan Zhou1, Qing Li1,2, Congyu Liao3, Xiaozhi Cao3, Ting Gong1, Qiuping Ding1, Hongjian He1, and Jianhui Zhong1,4
1Center for Brain Imaging Science and Technology, College of Biomedical Engineering and Instrumental Science, Zhejiang University, Hangzhou, China, 2MR Collaboration, Siemens Healthcare Ltd, Shanghai, China, 3Radiological Sciences Laboratory, Stanford University, Stanford, CA, United States, 4Department of Imaging Sciences, University of Rochester, Rochester, NY, United States

We proposed a 3D ultrashort echo time MR fingerprinting (3D UTE-MRF) method for whole brain myelin imaging in vivo and ex vivo. A series of dual-echo time images were acquired, and images optimized for long T2 tissue suppression were found in the second echo image series, which were used to extract myelin signals. Non-negative least-square was used to map the ultrashort T2 myelin tissue fraction. 3D UTE-MRF sequence can achieve whole brain myelin mapping in 15 min with 0.87 mm isotropic resolution.

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