Abstract #1544

3D Ultrashort Echo Time MR Fingerprinting (3D UTE-MRF) for Whole Brain Myelin Imaging

Zihan Zhou¹, Qing Li^1,2, Congyu Liao³, Xiaozhi Cao³, Ting Gong¹, Qiuping Ding¹, Hongjian He¹, and Jianhui Zhong^1,4

¹Center for Brain Imaging Science and Technology, College of Biomedical Engineering and Instrumental Science, Zhejiang University, Hangzhou, China, ²MR Collaboration, Siemens Healthcare Ltd, Shanghai, China, ³Radiological Sciences Laboratory, Stanford University, Stanford, CA, United States, ⁴Department of Imaging Sciences, University of Rochester, Rochester, NY, United States

We proposed a 3D ultrashort echo time MR fingerprinting (3D UTE-MRF) method for whole brain myelin imaging in vivo and ex vivo. A series of dual-echo time images were acquired, and images optimized for long T2 tissue suppression were found in the second echo image series, which were used to extract myelin signals. Non-negative least-square was used to map the ultrashort T2 myelin tissue fraction. 3D UTE-MRF sequence can achieve whole brain myelin mapping in 15 min with 0.87 mm isotropic resolution.

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