In this work, we developed ViSTa-MRF, which combined Visualization of Short Transverse relaxation time component (ViSTa) technique with MR Fingerprinting (MRF), to achieve whole-brain myelin-water fraction (MWF) and T1/T2/PD mapping at 1mm isotropic resolution in 10 minutes on a clinical 3T scanner. To achieve this fast acquisition, the ViSTa-MRF sequence also leverages an efficient 3D-spiral-projection acquisition along with spatiotemporal subspace reconstruction. With the proposed ViSTa-MRF method, direct MWF mapping was achieved without a need for multicompartment fitting. In comparison to conventional myelin-water imaging, the ViSTa-MRF method can provide improved-SNR and faster acquisition with high image-quality.
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