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Abstract #1545

High-resolution myelin-water fraction (MWF) and T1/T2/proton-density mapping using 3D ViSTa-MR fingerprinting with subspace reconstruction

Congyu Liao1, Xiaozhi Cao1, Ting Gong2, Zhe Wu3, Zihan Zhou2, Hongjian He2, Jianhui Zhong2,4, and Kawin Setsompop1
1Radiological Sciences Laboratory, Stanford University, Stanford, CA, United States, 2Center for Brain Imaging Science and Technology, College of Biomedical Engineering & Instrument Science, Zhejiang University, Hangzhou, China, 3Techna Institute, University Health Network, Toronto, ON, Canada, 4Department of Imaging Sciences, University of Rochester, Rochester, NY, United States

In this work, we developed ViSTa-MRF, which combined Visualization of Short Transverse relaxation time component (ViSTa) technique with MR Fingerprinting (MRF), to achieve whole-brain myelin-water fraction (MWF) and T1/T2/PD mapping at 1mm isotropic resolution in 10 minutes on a clinical 3T scanner. To achieve this fast acquisition, the ViSTa-MRF sequence also leverages an efficient 3D-spiral-projection acquisition along with spatiotemporal subspace reconstruction. With the proposed ViSTa-MRF method, direct MWF mapping was achieved without a need for multicompartment fitting. In comparison to conventional myelin-water imaging, the ViSTa-MRF method can provide improved-SNR and faster acquisition with high image-quality.

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