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Abstract #1612

MRI for evaluating compliance of aortic graft in a rat model and comparison to native aorta

El-Sayed H Ibrahim1, Xiaolong Wang1, and Bo Wang1
1Medical College of Wisconsin, Milwaukee, WI, United States

Vascular tissue-engineering provides an alternative solution to replace autologous vessels via developing an artificial vascular graft. To examine the in-vivo fate and understand the clinical potential of the artificial vascular graft, the graft was implanted into the abdominal aorta of Sprague-Dawley rats by end-to-end anastomosis. The goal of this study was to evaluate compliance and vessel wall stiffness in the artic graft and compare results to native aorta using MRI. The results demonstrated that the developed graft has biomechanical characteristics similar to those in native aorta, which may represent a potential avenue to construct a flexible vascular graft in patients.

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