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Abstract #1615

Optimization of Ultrashort TE protocol QUTE-CE with ferumoxytol for abdominal MRA

Tianyi Zhou1, Liam Timms1, Valur Olafsson2, Fred Bidmead2, Vishala Mishra3, Ravi T Seethamraju4, Mukesh Harisinghani3, and Srinivas Sridhar1
1Department of Physics, Northeastern University, Boston, MA, United States, 2Northeastern University Biomedical Imaging Center, Boston, MA, United States, 3Department of Radiology, Massachusetts General Hospital, Boston, MA, United States, 4Siemens Medical Solutions, Boston, MA, United States

A contrast-enhanced MRA protocol with Ultrashort Time-to-Echo (UTE) was optimized on phantoms covering a range of ferumoxytol concentrations for abdominal imaging. This approach produces images with high SNR (~ 4166) at clinical concentrations. The protocol was applied in vivo to human subjects for abdominal vascular imaging. Acquired human images demonstrated great delineation of central and peripheral vessels in the liver, kidneys and other abdominal organs. The combination of an optimized UTE sequence and the blood-pool kinetics of ferumoxytol enables high-resolution vascular imaging across the entire abdomen with maximized image quality. This technique could potentially aid in characterization of vascular diseases.

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