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Abstract #1614

Differentiating cardiac function and hemodynamics in treated and untreated models of aortic coarctation

El-Sayed H Ibrahim1, Jamasp Azarnoosh2, Arash Hassankiadeh1, Pierre Croisille3, Jadranka Stojanovska4, and John LaDisa2
1Medical College of Wisconsin, Milwaukee, WI, United States, 2Marquette University, Milwaukee, WI, United States, 3Jean-Monnet University, Lyon, France, 4University of Michigan, Ann Arbor, MI, United States

Aortic coarctation (CoA) is a congenital vascular disease characterized by severe narrowing of the proximal descending thoracic aorta, which affects 5,000-8,000 births annually in USA. Patients with CoA can have altered hemodynamics and remodeled left ventricle from increased afterload. In this study, we investigate the impact of CoA on cardiovascular parameters using rabbit models of treated and untreated CoA. The results showed that cardiovascular parameters can normalize in treated CoA compared to untreated cases and that myocardial strain and aortic blood velocity are sensitive parameters for differentiating between treated and untreated CoA as well as the severity of coarctation.

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