Abstract #1635

Using High Resolution MR microscopy to assess atherosclerosis in ApoE-KO mice fed diets of varying macronutrient content

Courtney Whalen¹, Sean Gullette², A. Catharine Ross¹, Rita Castro^1,3, and Thomas Neuberger^4,5

¹Nutritional Sciences, The Pennsylvania State University, University Park, PA, United States, ²Huck Institute of the Life Science, The Pennsylvania State University, University Park, PA, United States, ³University of Lisbon, Lisbon, Portugal, ⁴Huck Institute of the Life Science, University Park, PA, United States, ⁵Biomedical Engineering, The Pennsylvania State University, University Park, PA, United States

A ketogenic, low carbohydrate and extremely high fat, diet has been shown to positively impact CVD risk factors. Nevertheless, its effect on atherosclerosis has not been measured. Here, we used 14T MR microscopy to assess atherosclerotic plaque volume, localization, and regional plaque burden in apoE-KO mice fed a ketogenic diet compared to those fed a high fat diet or a control diet. Results show that a ketogenic diet had a protective effect against atherosclerosis compared to a high fat diet as measured by total plaque volume and plaque burden, this effect was not specific to individual regions of the aorta.

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