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Abstract #1636

Morphological and hemodynamic alterations of major brain feeding arteries across the lifespan

Zhe Sun1,2, Dengrong Jiang3, Marco Muccio1, Chenyang Li1,2, Zixuan Lin3, Peiying Liu3, Hanzhang Lu3, and Yulin Ge1
1Radiology, NYU Langone Health, New York, NY, United States, 2Vilcek Institute of Graduate Biomedical Science, New York University School of Medicine, New York, NY, United States, 3Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, United States

Vascular dysfunction is frequently found in neurodegenerative and cerebrovascular diseases and closely related to age. Bilateral internal carotid arteries (ICAs) and vertebral arteries (VAs) are the key feeding vessels of the brain, which may provide important indices of intracranial health status. We aimed to evaluate age-related morphological and hemodynamic changes of the vessels using TOF MRA and phase contrast MRI. More tortuous appearance as well as reduced hemodynamics were observed with aging; Blood velocity was found to be associated with the morphology after adjusting age and gender, indicating that high blood velocity and wall shear stress could induce arterial tortuosity.

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