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Abstract #1656

A Multi-Diffusion Model Investigation of White Matter Microstructure in Psychotic Spectrum Disorders

Faye McKenna1, Yu Veronica Sui2, Hillary Bertisch2, Donald Goff2, and Mariana Lazar2
1Radiology, New York University School of Medicine, New York, NY, United States, 2New York University School of Medicine, New York, NY, United States

We employed the recent Bingham neurite orientation dispersion and density imaging (NODDI-B) and diffusion kurtosis imaging (DKI) techniques, alongside classical diffusion tensor imaging (DTI) and found that psychotic spectrum disorders (PSD) and PSD sub-types had significantly increased mean and radial diffusion and orientation dispersion (MD, RD, ODI, ODIs) and significantly decreased mean and radial kurtosis (MK, RK), fractional anisotropy (FA) and neurite density index (NDI) in sub-cortical WM ROIs compared to healthy controls (HC). We also found significant relationships across PSD and HC groups between WM dMRI metrics and tests of episodic and working memory and several schizotypal traits.

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