Abstract #1657

Investigation of Microstructural Alterations of the Corpus Callosum in Autism Using Multi-Shell Diffusion MRI and Quantitative Relaxometry

Douglas C Dean^1,2,3, Nagesh Adluru³, Jace B King⁴, Molly B Prigge⁴, Carolyn King⁴, Erin D Bigler^5,6,7,8, June Taylor⁴, Nick Lange⁹, Brandon A Zielinski^4,5,10, Janet E Lainhart^3,11, and Andrew L Alexander^2,3,11

¹Pediatrics, University of Wisconsin–Madison, Madison, WI, United States, ²Medical Physics, University of Wisconsin–Madison, Madison, WI, United States, ³Waisman Center, University of Wisconsin–Madison, Madison, WI, United States, ⁴Radiology, University of Utah, Salt Lake City, UT, United States, ⁵Neurology, University of Utah, Salt Lake City, UT, United States, ⁶Psychiatry, University of Utah, Salt Lake City, UT, United States, ⁷Psychology and Neuroscience Center, Brigham Young University, Provo, UT, United States, ⁸Neurology, University of California–Davis, Davis, CA, United States, ⁹Psychiatry, Harvard School of Medicine, Boston, MA, United States, ¹⁰Pediatrics, University of Utah, Salt Lake City, UT, United States, ¹¹Psychiatry, University of Wisconsin–Madison, Madison, WI, United States

White matter microstructural alterations are consistently reported and believed to play a significant role in the defining characteristics of autism spectrum disorder. In this work, we utilized advanced diffusion imaging and quantitative relaxometry to examine microstructural differences in autism. We observe significant group and age-related deviations of the corpus callosum, as well as more widespread alterations of the neurite microstructure. These results are consistent with previous findings of the corpus callosum in ASD and suggest that while sensitive to underlying microstructural deviations, advanced diffusion imaging and relaxometry provide complementary information.

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