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Abstract #1658

Association of anterior cingulate glutathione and degree of depression in unmedicated bipolar disorder – a 7T study

Pallab K Bhattacharyya1, Mark J Lowe1, and Amit Anand1
1Cleveland Clinic Foundation, CLEVELAND, OH, United States

Oxidative stress is a contributing factor in bipolar disorder (BD). Glutathione (GSH) acts as an antioxidant and reduces oxidative stress. GSH level at anterior cingulate cortex was measured in unmedicated patients with BD in depressed state and healthy controls at 7T using semi-LASER sequence. No significant difference in GSH level was observed; however, degree of depression was inversely correlated with GSH level.

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