Changes in total choline level in left anterior cingulate cortex (ACC) following lithium monotherapy of bipolar disorder in depressed state were studied at 7T. Patients were scanned with a semi LASER sequence at baseline and 2, 8 and 26 weeks from start of therapy. Healthy controls were also scanned at those 4 time points. A decrease in choline level at left dorsal/rostral ACC was observed in patients, and the reduction took place between 8 and 26 weeks after onset of therapy.
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