Abstract #1660

Functional and structural brain alterations in anorexia nervosa: a multimodal meta-analysis of neuroimaging studies

Ting Su¹, Jia ying Gong², Shao juan Qiu¹, Pan Chen¹, Guan mao Chen¹, Jun jing Wang³, Li Huang¹, and Ying Wang¹

¹Medical Imaging Center, First Affiliated Hospital of Jinan University, Guangzhou, China, ²Department of Radiology, Six Affiliated Hospital of Sun Yat-sen University, Guangzhou, China, ³Department of Applied Psychology, Guangdong University of Foreign Studies, Guangzhou, China

Anorexia nervosa (AN) is a complex psychiatric disorder with poorly understood etiology. A whole-brain meta-analysis on resting-state functional imaging and VBM studies that measured differences in the intrinsic functional activity and gray matter volume (GMV) between AN patients and healthy controls. Overall, patients with AN displayed decreased resting-state functional activity in the bilateral ACC and MCC and increased in the right parahippocampal gyrus. In VBM studies, with AN patients displayed decreased GMV in the bilateral MCC , and left inferior parietal lobe. This multimodal meta-analysis identified functional activity and GMV reductions in the anterior and median cingulate in patients with AN.

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