Abstract #1663

Circadian rhythm functional network in the central nervous system and its disruptions in chronic insomnia disorder

Ran Pang^1,2, Jianli Wang³, Karunanayaka Prasanna³, Kuncheng Li⁴, and Qingxian Yang²

¹Department of Radiology, Dongfang Hospital, Beijing University of Chinese Medicine, Beijing, China, ²Department of Neurosurgery, Pennsylvania State University College of Medicine, Hershey, PA, United States, ³Department of Radiology, Pennsylvania State University College of Medicine, Hershey, PA, United States, ⁴Department of Radiology, Xuanwu Hospital, Capital Medical University, Beijing, China

The etiology of chronic insomnia disease (CID) ultimately relates to the asynchrony of circadian rhythms. Using the anterior hypothalamus as a seed, functional connectivity (FC) of the circadian rhythm functional network (CRFN) during resting state was demonstrated in healthy subjects, consisting of both positive and negative FCs in the cerebrum and cerebellum. The CID patients exhibited an extensive weakening of FCs and abnormal local hyperactivities, reflecting underlying asynchrony in the CRFN.

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