Abstract #1664

7T Mental health: Functional alterations in resting-state within the executive control network and its association with BDI-II and TMT-B in MDD

Ravichandran Rajkumar^1,2,3, Gereon Johannes Schnellbächer², Hasan Sbaihat^1,2, N. Jon Shah^1,4,5,6, Tanja Veselinović², and Irene Neuner^1,2,4

¹Institute of Neuroscience and Medicine - 4 (Medical Imaging Physics), Forschungszentrum Juelich GmbH, Jülich, Germany, ²Department of Psychiatry, Psychotherapy and Psychosomatics, RWTH Aachen University, Aachen, Germany, ³4JARA – BRAIN – Translational Medicine, Aachen, Germany, ⁴JARA – BRAIN – Translational Medicine, Aachen, Germany, ⁵Department of Neurology, RWTH Aachen University, Aachen, Germany, ⁶Institute of Neuroscience and Medicine, INM-11, Forschungszentrum Jülich GmbH, Jülich, Germany

Executive functioning is reported to be deficient in depression. In this pilot study, functional alterations in MDD patients and their association with mental flexibility and depression severity, particularly within the executive control network, are investigated. Our data contribute to a better understanding of the neurobiological signatures of depression. Further investigation in this area may lead to an improvement in the diagnosis and treatment of MDD patients.

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