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Abstract #1666

MRI measurements demonstrate gray matter increases induced by transcranial direct current stimulation treatment in depression

Mayank Jog1, Cole Anderson1, Elizabeth Kim1, Antoni Kubicki1, Michael Boucher1, Gerhard Hellemann2, Roger Woods1, and Katherine Narr1
1UCLA, Los Angeles, CA, United States, 2University of Alabama, Birmingham, Birmingham, AL, United States

Transcranial direct current stimulation (tDCS) is a low-cost and non-invasive neuromodulation technique. Although tDCS has been shown to improve symptoms in psychiatric disorders, the neurobiological effects of tDCS are not well-understood. In this study, we used MRI to investigate structural changes in the brain resulting from tDCS. T1-weighted MRI data from n=59 depressed participants was acquired pre/post tDCS treatment, and analysis revealed gray-matter increases near the stimulation-target and in a distant but functionally-connected region. These results indicate that tDCS treatments can elicit structural changes in the brain; both near the stimulation-target and in additional regions part of the same brain-network.

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