Transcranial direct current stimulation (tDCS) is a low-cost and non-invasive neuromodulation technique. Although tDCS has been shown to improve symptoms in psychiatric disorders, the neurobiological effects of tDCS are not well-understood. In this study, we used MRI to investigate structural changes in the brain resulting from tDCS. T1-weighted MRI data from n=59 depressed participants was acquired pre/post tDCS treatment, and analysis revealed gray-matter increases near the stimulation-target and in a distant but functionally-connected region. These results indicate that tDCS treatments can elicit structural changes in the brain; both near the stimulation-target and in additional regions part of the same brain-network.
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