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Abstract #1667

Alternations of functional networks in adult PTSD: a systematic review and meta-analysis of resting-state functional connectivity studies

WeiJie Bao1, YingXue Gao1, Hailong Li1, jing Liu1, Lingxiao Cao1, Xuan Bu1, and Xiaoqi Huang1
1Huaxi MR Research Center (HMRRC), Functional and Molecular Imaging Key Laboratory of Sichuan Province, Department of Radiology, West China Hospital, Sichuan University, Chengdu, China

We performed a systematic review of studies which explored network alterations by comparing PTSD and trauma-exposed controls (TEC) or nonexposed controls (NEC) using seed-based functional connectivity (SBFC) techniques. And quantitative meta-analysis was conducted when the number of studies reached an appropriate number. Our results supported that trauma may have long-lasting effects on the function of the default mode network (DMN) and limbic network (LN) regardless of whether it caused symptoms of PTSD. Moreover, the altered connectivity between the DMN and the somatomotor network (SMN) and between the LN and SMN may be underline neural mechanism specify to PTSD.

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