Background: The current outbreak of the novel coronavirus disease 2019 (COVID-19), has rapidly spread across China and many other countries.Subthreshold depression (SD) is generally considered to present when individuals show depressive symptoms but diagnostic criteria for a major depressive disorder are not met. Methods: In total,49 SD individuals and 56 health controls(HC) were recruited from Jinan University. All subjects underwent MRI and MATRICS Consensus Cognitive Battery (MCCB) before COVID-19 outbreak. Conclusion: After the COVID-19 epidemic situation, changes of brain area and cognitive function of college students with significant stress symptoms were more obvious.
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