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Abstract #1680

Fibre-specific white matter changes in neonates born to women prescribed methadone in pregnancy

Manuel Blesa Cábez1, Thijs Dhollander2, Victoria J Monnelly1, Alan J Quigley3, Scott I Semple4, Mark E Bastin4, and James P Boardman1
1MRC Centre for Reproductive Health, University of Edinburgh, Edinburgh, United Kingdom, 2Developmental Imaging, Murdoch Children's Research Institute, Melbourne, Australia, 3Department of Radiology, Royal Hospital for Sick Children, Edinburgh, United Kingdom, 4Edinburgh Imaging, University of Edinburgh, Edinburgh, United Kingdom

Methadone is often used for medication-assisted treatment of heroin addiction during pregnancy. Children with prenatal exposure to the drug are at increased risk of neurodevelopmental and behavioural impairment. We did fixel-based analysis with a group of 20 term born infants whose mothers had been prescribed methadone during pregnancy for the treatment of heroin addiction and a control group of 20 control infants. There was significant widespread reduction across the WM in fiber-bundle cross-section and fiber density and cross-section in the exposed group, this suggests that affected fibre bundles are less developed, similar to WM structures in preterm born babies.

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