Abstract #1691

Assessment of microstructural changes following pediatric traumatic brain injury by advanced diffusion imaging

Yohan van de Looij^1,2, Alice Jacquens^3,4, Pierre Gressens^4,5, Vincent Degos^3,4, and Stéphane V Sizonenko¹

¹Division of Development and Growth, Department of Paediatrics and Gynaecology-Obstetrics, University of Geneva, Geneva, Switzerland, ²Center for Biomedical Imaging, Animal Imaging Technology section, Federal Institute of Technology of Lausanne, Lausanne, Switzerland, ³Department of Anesthesia and Intensive Care, Pitié-Salpêtrière Hospital, Paris, France, ⁴PROTECT, INSERM, Université Paris Diderot, Sorbonne Paris Cité, Paris, France, ⁵Centre for the Developing Brain, School of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom

Traumatic brain injury (TBI) on the immature brain can have dramatic consequences on cerebral development. Understanding the underlying lesions of this abnormal development is of high interest. In this work, we used a mouse model of pediatric TBI at Postnatal day 7 (P7 - impact acceleration model) and assessed the long-term subsequent microstructural damages (at P45) using DTI and NODDI at 9.4T. Severe changes in white matter and cortical developments were observed. In conclusion, DTI derived parameters as well as NODDI estimates allow an accurate determination of the location and extent of the brain lesions following TBI.

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