Abstract #1692

Characterization of individual DTI measurement age trajectories in a longitudinal study of autism spectrum disorder

Nagesh Adluru¹, Douglas C Dean III¹, Molly Prigge², Jace B King², Nicholas T Lange³, Erin D Bigler⁴, Brandon Zielinski², Janet E Lainhart¹, and Andrew L Alexander¹

¹UW-Madison, Madison, WI, United States, ²University of Utah, Salt Lake City, UT, United States, ³Harvard Medical School, Boston, MA, United States, ⁴Brigham Young University, Provo, UT, United States

The purpose of this analysis is to investigate the patterns of individual rates of change of diffusion tensor imaging (DTI) measures computed from a longitudinal study of autism spectrum disorder (ASD). The mean value and temporal rates of change of DTI measures were estimated for regions of white matter for individual subjects. The distributions of the individual longitudinal slopes versus mean measures for ASD and typically developing controls (TDC) were mapped and compared, revealing group differences in the distributions with generally greater heterogeneity in the ASD group.

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