Abstract #1707

Effect of age on white matter microstructure in nondemented ApoE4 carriers and non-carriers

Patcharaporn Srisaikaew^1,2, Jordan A. Chad^3,4, Pasuk Mahakkanukrauh^1,5, Nicole D. Anderson^3,6, and J. Jean Chen^3,4

¹Department of Anatomy, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand, ²PhD Program in Anatomy, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand, ³Rotman Research Institute, Baycrest Health Centre, Toronto, ON, Canada, ⁴Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada, ⁵Excellence in Osteology Research and Training Center (ORTC), Chiang Mai University, Chiang Mai, Thailand, ⁶Department of Psychology and Psychiatry, University of Toronto, Toronto, ON, Canada

With advancing age, ApoE4 increases the risk of developing AD compared to non-carriers. TBSS analysis and FSL’s randomise permutation tool were used to test diffusivity (FA, MD, RD, AxD, MO, and NA) differences in the effect of age in nondemented ApoE4+ compared to ApoE4- older adults. The difference between groups in the association of DTI metrics and age was most present in posterior WM regions. MO and NA were more sensitive to age-related effects than conventional DTI metrics in crossing fibres. We support the changes in DTI metrics due to the manifestation of the ApoE4 across whole-brain age-related WM microstructures.

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