Patcharaporn Srisaikaew1,2, Jordan A. Chad3,4, Pasuk Mahakkanukrauh1,5, Nicole D. Anderson3,6, and J. Jean Chen3,4
1Department of Anatomy, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand, 2PhD Program in Anatomy, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand, 3Rotman Research Institute, Baycrest Health Centre, Toronto, ON, Canada, 4Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada, 5Excellence in Osteology Research and Training Center (ORTC), Chiang Mai University, Chiang Mai, Thailand, 6Department of Psychology and Psychiatry, University of Toronto, Toronto, ON, Canada
With advancing age, ApoE4 increases the risk of developing AD compared to non-carriers. TBSS analysis and FSL’s randomise permutation tool were used to test diffusivity (FA, MD, RD, AxD, MO, and NA) differences in the effect of age in nondemented ApoE4+ compared to ApoE4- older adults. The difference between groups in the association of DTI metrics and age was most present in posterior WM regions. MO and NA were more sensitive to age-related effects than conventional DTI metrics in crossing fibres. We support the changes in DTI metrics due to the manifestation of the ApoE4 across whole-brain age-related WM microstructures.