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Abstract #1708

Longitudinal Brain Atlases of Early Developing Cynomolgus Macaques from Birth to 48 Months of Age

Tao Zhong1,2, Liangjun Chen2, Fenqiang Zhao2, Zhengwang Wu2, Yuchen Pei2, Ya Wang2, Li Wang2, Yuyu Niu3, Yu Zhang1, and Gang Li2
1Southern Medical University, Guangzhou, China, 2University of North Carolina at Chapel Hill, Chapel Hill, NC, United States, 3Kunming University of Science and Technology, Kunming, China

In analyzing the early postnatal brain development featuring extremely dynamic imaging contrast, brain appearance, shape and size, longitudinal brain atlases with densely sampled time-points and ancillary anatomical information are of great importance, but remain absent in cynomolgus macaques, which is a highly valuable animal model for understanding human brains. To fill this critical gap, we construct the first set of spatiotemporal (4D) brain atlases and associated ancillary anatomical information with 12 time-points (i.e., 1, 2, 3, 4, 5, 6, 9, 12, 18, 24, 36, and 48 months of age) based on 175 longitudinal structural MRI scans from 46 cynomolgus macaques.

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