Abstract #1709

Widespread effect of age related macular degeneration on brain structural integrity.

Jacques Andrew Stout¹, Robert BJ Anderson², Simon Wilton Davis³, Jie Zhuang^3,4, David Dunson^5,6, Heather Elisabeth Whitson⁷, and Alexandra Badea^1,2,3

¹BIAC, Duke School of Medicine, Durham, NC, United States, ²Duke Radiology, Duke School of Medicine, Durham, NC, United States, ³Duke Neurology, Duke School of Medicine, Durham, NC, United States, ⁴School of Psychology, Shanghai University of Sport, Shanghai, China, ⁵Statistics, Duke University, Durham, NC, United States, ⁶Trinity College of Arts & Sciences, Duke University, Durham, NC, United States, ⁷Geriatrics, Duke School of Medicine, Durham, NC, United States

Age-related macular degeneration (AMD) has been associated with brain degeneration, particularly in the cortical regions of the brain. Our study involved the comparison of subjects with AMD to subjects, with both an initial scan at the beginning of the study, and a secondary one two years later. Using anatomical and diffusion acquisitions, we ascertained that there was a marked decrease in cortical volumetry and fractional anisotropy (FA), and that it evolved very rapidly in the case of FA. A PCA run on the connectivity matrices also identified the connections that were most affected.

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