Age-related macular degeneration (AMD) has been associated with brain degeneration, particularly in the cortical regions of the brain. Our study involved the comparison of subjects with AMD to subjects, with both an initial scan at the beginning of the study, and a secondary one two years later. Using anatomical and diffusion acquisitions, we ascertained that there was a marked decrease in cortical volumetry and fractional anisotropy (FA), and that it evolved very rapidly in the case of FA. A PCA run on the connectivity matrices also identified the connections that were most affected.
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