Abstract #1710

Spiral diffusion imaging at 800 µm resolution using a scanner with 300 mT/m gradients and gradient field monitoring

Luke Joel Edwards¹, Kerrin J. Pine¹, Shubhajit Paul¹, Fakhereh Movahedian Attar¹, Michael Herbst², Mirsad Mahmutović³, Boris Keil³, Harald Möller⁴, Evgeniya Kirilina^1,5, and Nikolaus Weiskopf^1,6

¹Department of Neurophysics, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany, ²Gengenbach, Germany, ³Institute of Medical Physics and Radiation Protection, TH Mittelhessen University of Applied Sciences, Giessen, Germany, ⁴NMR Group, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany, ⁵Center for Cognitive Neuroscience Berlin, Freie Universität Berlin, Berlin, Germany, ⁶Felix Bloch Institute for Solid State Physics, Leipzig University, Leipzig, Germany

Spiral diffusion weighted imaging (DWI) with field monitoring and iterative reconstruction offers potentially reduced echo time (TE) and higher effective resolution (less blurring) compared to EPI. Coupled with a scanner with ultra-strong gradients, it enabled an 800 µm DWI protocol for imaging fine structures of the brain in vivo. Compared to EPI, the shorter TEs provided distinctly different contrast in iron-rich areas (U-fibres and sub-cortical nuclei), which could enhance investigations of these regions. The protocol did, however, come with a reduction in SNR/(unit time) compared to EPI due to differences in readout time.

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