Luke Joel Edwards1, Kerrin J. Pine1, Shubhajit Paul1, Fakhereh Movahedian Attar1, Michael Herbst2, Mirsad Mahmutović3, Boris Keil3, Harald Möller4, Evgeniya Kirilina1,5, and Nikolaus Weiskopf1,6
1Department of Neurophysics, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany, 2Gengenbach, Germany, 3Institute of Medical Physics and Radiation Protection, TH Mittelhessen University of Applied Sciences, Giessen, Germany, 4NMR Group, Max Planck Institute for Human Cognitive and Brain Sciences, Leipzig, Germany, 5Center for Cognitive Neuroscience Berlin, Freie Universität Berlin, Berlin, Germany, 6Felix Bloch Institute for Solid State Physics, Leipzig University, Leipzig, Germany
Spiral diffusion weighted imaging (DWI) with field monitoring and iterative reconstruction offers potentially reduced echo time (TE) and higher effective resolution (less blurring) compared to EPI. Coupled with a scanner with ultra-strong gradients, it enabled an 800 µm DWI protocol for imaging fine structures of the brain in vivo. Compared to EPI, the shorter TEs provided distinctly different contrast in iron-rich areas (U-fibres and sub-cortical nuclei), which could enhance investigations of these regions. The protocol did, however, come with a reduction in SNR/(unit time) compared to EPI due to differences in readout time.