Orientation-dependent transverse ($$$R_2$$$ and $$$R_2^*$$$) relaxation phenomena have been documented in the human brain white matter, yet the underlying relaxation mechanisms still remain not well understood. This work is to propose an alternative relaxation pathway through restricted molecular rotational diffusion, in terms of a generalized magic angle effect (gMAE) model, to better characterize recently reported anisotropic $$$R_2$$$ of myelin water and intra- and extracellular water in vivo at 3T. The proposed gMAE model is intrinsically connected with anisotropic translational diffusion from DTI, elucidating not only previously reported $$$R_2^*$$$ anisotropy ex vivo but also its temperature-dependence at 7T.
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