Abstract #1714

Technical performance of ADC and IVIM measurements in glioma and normal brain on a 1.5T MR-Linac

Liam S. P. Lawrence¹, Rachel W. Chan², Hanbo Chen³, Brian Keller³, James Stewart³, Mark Ruschin³, Brige Chugh^3,4, Mikki Campbell³, Aimee Theriault³, Greg J. Stanisz^1,2,5, Scott MacKenzie³, Sten Myrehaug³, Jay Detsky³, Pejman J. Maralani⁶, Chia-Lin Tseng³, Greg J. Czarnota^1,2,3, Arjun Sahgal³, and Angus Z. Lau^1,2

¹Medical Biophysics, University of Toronto, Toronto, ON, Canada, ²Physical Sciences, Sunnybrook Research Institute, Toronto, ON, Canada, ³Department of Radiation Oncology, Sunnybrook Health Sciences Centre, Toronto, ON, Canada, ⁴Department of Physics, Ryerson University, Toronto, ON, Canada, ⁵Department of Neurosurgery and Paediatric Neurosurgery, Medical University of Lublin, Lublin, Poland, ⁶Department of Medical Imaging, University of Toronto, Sunnybrook Health Sciences Centre, Toronto, ON, Canada

Technical performance evaluation of diffusion parameters on MR-Linacs (MRLs) is important for cancer applications. We evaluated the accuracy and repeatability of 1.5T MRL measurements of apparent diffusion coefficient (ADC) and intravoxel incoherent motion blood volume fraction (IVIM-f) in the brain via comparison with a diagnostic-quality scanner, in patients undergoing treatment. ADC measurements agree in normal and tumour tissue, but are biased in cerebrospinal fluid. IVIM-f measurements are likely negatively biased. Repeatability is comparable between scanners. The majority of high-grade glioma patients demonstrated significant ADC changes, but not IVIM-f changes.

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