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Abstract #1718

In Vivo Diffusion Tensor Distribution MRI of the Human Brain Using 300 mT/m Gradients

Kulam Najmudeen Magdoom1, Alexandru V. Avram1, Dario Gasbarra2, Qiuyun Fan3, Thomas Witzel3, Susie Y Huang3, and Peter J Basser1
1National Institute of Health, Bethesda, MD, United States, 2University of Helsinki, Helsinki, Finland, 3Massachusetts General Hospital and Harvard Medical School, Charlestown, MA, United States

Measuring and mapping the diffusion tensor distribution (DTD) via MRI holds the promise of revealing the tissue microstructure at sub-voxel resolution. In this study, we show the DTD results obtained on a human brain in-vivo using the new framework at MGH Connectome scanner with 300 mT/m gradients. The DTD within a voxel is assumed to be a normal tensor variate distribution constrained (CNTVD) within the manifold of 3 x 3 symmetric positive definite matrices. The estimated DTD is used to obtain a family of metrics which aim to disentangle size, shape and orientation heterogeneities present within a voxel.

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