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Abstract #1721

Multimodal Apparent Diffusion (MAD) Magnetic Resonance Imaging with comprehensive quantification of diffusion in the brain

Frederick C. Damen1, Alessandro Scotti1, Frederick W. Damen2, Nitu Saran1, Tibor Valyi-Nagy3, Mirko Vukelich1, and Kejia Cai1
1Radiology, University of Illinois at Chicago, Chicago, IL, United States, 2Biomedical Engineering, Purdue University, West Lafayette, IN, United States, 3Pathology, University Of Illinois at Chicago, Chicago, IL, United States

In physiological and pathological conditions in which multiple underlying tissue properties are expected to vary the diffusion weighted signal, the diagnostic value of conventional apparent diffusion coefficient (ADC) notably decreases. The proposed method extracts four separate distributions, i.e., modes, of diffusion weighted signal, which includes flow and unimpeded, hindered, and restricted diffusion, thereby increasing the precision of quantification of the hindered diffusion in grey and white matters.

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