We propose a novel, semi-automated approach to assess corpus callosum integrity at the individual level, based on the spatial distribution of the principal diffusion direction orientation. We applied the method to the clinical challenge of differentiating normal pressure hydrocephalus (iNPH, N=23) from progressive supranuclear palsy (PSP, N=27) and Alzheimer’s Disease (AD, N=35), whose shared clinical and radiological features can make early differential diagnosis difficult. We found differential involvement of PDD distribution across neurodegenerative (AD, PSP) and non-degenerative diseases (such as iNPH), a finding that could shed light on the different mechanisms that underlie tissue damage.
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