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Abstract #1723

Semi-automated assessment of the principal diffusion direction in the corpus callosum: application across brain diseases

Maria Eugenia Caligiuri1, Andrea Quattrone2, Alessandro Mechelli2, and Aldo Quattrone1
1Neuroscience Research Center, University "Magna Graecia", Catanzaro, Italy, 2Institute of Neurology, University "Magna Graecia", Catanzaro, Italy

We propose a novel, semi-automated approach to assess corpus callosum integrity at the individual level, based on the spatial distribution of the principal diffusion direction orientation. We applied the method to the clinical challenge of differentiating normal pressure hydrocephalus (iNPH, N=23) from progressive supranuclear palsy (PSP, N=27) and Alzheimer’s Disease (AD, N=35), whose shared clinical and radiological features can make early differential diagnosis difficult. We found differential involvement of PDD distribution across neurodegenerative (AD, PSP) and non-degenerative diseases (such as iNPH), a finding that could shed light on the different mechanisms that underlie tissue damage.

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