The widespread incidence of infection from the novel coronavirus SARS-CoV-2 has prompted many research MRI facilities to require scan subjects to wear masks during scanning in order to diminish the risk of virus transmission. Wearing an efficacious mask will mix some expired air with fresh air, and lead to increased carbon dioxide concentration [CO2] in inspired air. The question we approached is: Since CO2 is a potent vasodilator, does this elevation in [CO2] alter functional MRI (fMRI)?
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