Meeting Banner
Abstract #1741

Cerebral Microstructural Alteration in Follow-up COVID-19 Patients: A Diffusion Kurtosis Imaging Study

Minhua Yu1, Weiyin Vivian Liu2, Qunfeng Wang3, Dan Xu1, Yumin Liu3, and Haibo Xu1
1Radiology, Zhongnan Hospital of Wuhan University, Wuhan, China, 2MR Research, GE Healthcare, Beijing, China, 3Neurology, Zhongnan Hospital of Wuhan University, Wuhan, China

This study aims to investigate the cerebral microstructural alteration of follow-up recovered COVID-19 (rCOVID-19) patients and explore the corrections of symptoms and microstructure changes. Decreased axial kurtosis (Kax), radial kurtosis (Krad), mean kurtosis (Kmean), mean kurtosis tensor (KTmean) and increased fractional anisotropy (FA) in several brain regions of rCOVID-19 patients indicated demyelination and increased cell membrane permeability of cerebral cortex. Hyposmia was negatively correlated with Kmean and Krad in right anterior cingulum of rCOVID-19 patients, partly explaining the residual olfactory impairment several months after recovery. DKI metrics can help reveal microstructural changes of CNS for rCOVID-19 patients.

This abstract and the presentation materials are available to members only; a login is required.

Join Here