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Abstract #1742

 Advanced magnetic resonance imaging to study brain tissue alterations in people infected with SARS-COV-2

Claudia A.M. Gandini Wheeler-Kingshott1,2,3, Marios C. Yiannakas1, Janine Makaronidis4,5,6, Ferran Prados7,8, Baris Kanber7, Bhavana S. Solanky1, Marco Battiston1, Jed Wingrove4, Francesco Grussu1,7,9, Gloria Castellazzi10,11, Jonathan Stutters1, James McStravick1, Anita Karsa12, Rebecca Samson1, Karin Shmueli12, Xavier Golay13, Geoff J. M. Parker1,7, Daniel C. Alexander7, Yael Hacohen1, Egidio D'Angelo2,3, Frederik Barkhof13,14, Carmen Tur1,15, Louis Grandjean16, Olga Ciccarelli1, and Rachel L. Batterham4,5,6
1NMR Research Unit, Queen Square MS Centre, Department of Neuroinflammation, UCL Queen Square Institute of Neurology, Faculty of Brain Sciences, University College London (UCL), London, United Kingdom, 2Department of Brain & Behavioural Sciences, University of Pavia, Pavia, Italy, 3Brain Connectivity Center Research Department, IRCCS Mondino Foundation, Pavia, Italy, 4UCL Centre for Obesity Research, Division of Medicine, University College London (UCL), London, United Kingdom, 5Bariatric Centre for Weight Management and Metabolic Surgery, University College London Hospital (UCLH), London, United Kingdom, 6National Institute of Health Research, UCLH Biomedical Research Centre, London, United Kingdom, 7Centre for Medical Image Computing, University College London (UCL), London, United Kingdom, 8E-Health Center, Universitat Oberta de Catalunya, Barcelona, Spain, 9Radiomics Group, Vall d’Hebron Institute of Oncology, Vall d’Hebron Barcelona Hospital Campus, Barcelona, Spain, 10IRCCS Mondino Foundation, Pavia, Italy, 11Department of Electrical, Computer and Biomedical Engineering, University of Pavia, Pavia, Italy, 12Department of Medical Physics & Biomedical Engineering, University College London (UCL), London, United Kingdom, 13Department of Brain Repair & Rehabilitation, University College London (UCL), London, United Kingdom, 14Radiology, VU Medical Centre Amsterdam, Amsterdam, Netherlands, 15Neurology-Neuroimmunology Department, Multiple Sclerosis Centre of Catalonia (Cemcat), Vall d’Hebron Barcelona Hospital Campus, Barcelona, Spain, 16Department of Infection, Inflammation and Immunity, Institute of Child Health, University College London (UCL), London, United Kingdom

COVID-19 has now been associated with neurological symptoms, but the pathogenesis of such symptoms is unknown. Advanced quantitative MRI can provide information on alterations of brain tissue properties beyond clinically identifiable lesions. We developed a novel comprehensive scanning protocol and highly automated analysis pipeline to compare brain structure and function in people who were exposed to SARS-COV-2 infection against people who were not. Initial findings indicate that COVID-19 alters white matter microstructure and brain metabolism.

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