Increasing evidences support that SARS-CoV-2 can invade the central nervous system (CNS) and damage neuronal cells. However, there is no study to unravel the brain microstructural changes associated with SARS-CoV-2. Synthetic MRI provides T1 and T2 mapping, which could quantitatively evaluate the tissue microstructures. In current study, our goal is to assess the microstructural involvement of gray matter in recovered COVID-19 patients using Synthetic MRI. Our results indicated that the microstructure component of gray matter is disrupted in recovered COVID-19 patients, which provided the evidence of CNS damages.
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