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Abstract #1745

Towards to quantitative evaluation of brain damages in recovered COVID-19 patients using Synthetic MRI

Xie Qing1, Niu Shanshan1, Liao Jianwei1, Li Yingqin1, Qian Long2, Zhang Yaqin1, and Li Shaolin1
1Department of Radiology, the Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai, Guangdong, China, 2MR Research, GE Healthcare, Beijing, China

Increasing evidences support that SARS-CoV-2 can invade the central nervous system (CNS) and damage neuronal cells. However, there is no study to unravel the brain microstructural changes associated with SARS-CoV-2. Synthetic MRI provides T1 and T2 mapping, which could quantitatively evaluate the tissue microstructures. In current study, our goal is to assess the microstructural involvement of gray matter in recovered COVID-19 patients using Synthetic MRI. Our results indicated that the microstructure component of gray matter is disrupted in recovered COVID-19 patients, which provided the evidence of CNS damages.

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