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Abstract #1746

Imaging lung structure and function in acute COVID-19 patients with 129Xe and 1H MRI

Guilhem J Collier1, Jody Bray1, Ho-Fung Chan1, Paul J.C. Hughes1, James A Eaden1, Laurie J Smith1, Helen Marshall1, David J Capener1, Leanne Armstrong1, Alberto M Biancardi1, Madhwesha R Rao1, Graham Norquay1, Oliver Rodgers1, Andy J Swift1, Smitha Rajaram2, Fergus Gleeson3, James T Grist3, Gary H Mills4, James Meiring2, Lisa Watson2, Paul J Collini4, Roger Thompson4, Rod Lawson2, and Jim M Wild1
1POLARIS, Department of Infection, Immunity & Cardiovascular Disease, University of Sheffield, Sheffield, United Kingdom, 2Sheffield teaching hospitals, NHS Foundation TRUST, Sheffield, United Kingdom, 3Department of Radiology, Oxford NHS Foundation Trust, Oxford, United Kingdom, 4Department of Infection, Immunity & Cardiovascular Disease, University of Sheffield, Sheffield, United Kingdom

We assessed the sensitivity of a comprehensive multi-nuclear lung function-structure imaging protocol to acute changes in the lungs of patients admitted to hospital with COVID-19 lung infection. Dissolved 129Xe spectroscopic imaging and DCE 1H perfusion MRI indicate impaired gas transfer related to diffusion and microvascular perfusion limitation, whilst 129Xe ventilation MRI and 129Xe DWI indicate fairly homogenous lung ventilation and airway microstructure, apart from in areas showing clear structural abnormality on UTE/ZTE imaging (residual ground glass opacity or consolidation). The findings provide quantitative regional insight in to why patients suffer from severe breathlessness despite their lung ventilation appearing near normal.

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