Abstract #1798

Treatment-induced changes in 2H-labeled lactate measured by 2H magnetic resonance spectroscopy are associated with apoptotic cell death

Josephine L Tan^1,2, Daniel Djayakarsana^1,2, Hanzhi Wang^1,2, Rachel W Chan², Colleen Bailey^1,2, and Angus Z Lau^1,2

¹Medical Biophysics, University of Toronto, Toronto, ON, Canada, ²Physical Sciences, Sunnybrook Research Institute, Toronto, ON, Canada

Elevated lactate production, a key characteristic of the aberrant tumour metabolism, can be detected non-invasively by deuterium (²H) magnetic resonance spectroscopy (MRS). To determine if ²H-labeled lactate measured by ²H MRS can serve as an early marker of tumour response, we investigate the association of treatment-induced signal changes in ²H-lactate in vitro with apoptotic cell death. We show that significantly lower ²H-lactate in 48-hour cisplatin treated cells (1.6 ± 0.4 mM) compared to those untreated (3.2 ± 0.4 mM) and 24-hour treated cells (4.0 ± 0.6 mM) is associated with with an increase in apoptotic area fraction.

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