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Abstract #1797

MRI visualization of neurogenesis with ferritin and eGFP gene reporters in the intact and post-ischemic rat brain

Marina Y Khodanovich1, Andrey E Akulov2, Tatyana V Anan’ina1, Elena P Krutenkova1, and Anna V Naumova3
1Research Institute of Biology and Biophysics, Tomsk State University, Tomsk, Russian Federation, 2Institute of Cytology and Genetics, Novosibirsk, Russian Federation, 3Radiology, University of Washington, Seattle, WA, United States

The present work demonstrates feasibility of longitudinal visualization of neurogenesis in vivo with MRI gene reporter ferritin and fluorescent reporter eGFP expressed under the doublecortin promoter. Main source of the signal hypointensity in the brain neurogenic zones were mature and young neurons. Main source of the signal hypointensity in the ischemic lesion area were macrophages.

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