Abstract #1796

Measuring CMRO2 in Brain Subcortical Structures Using Dynamic 17O-MRI

Hao Song¹, Burak Akin¹, Johannes Fischer¹, Ali Caglar Özen^1,2, Stefan Schumann³, and Michael Bock^1,2

¹Dept. of Radiology, Medical Physics, Medical Center University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany, ²German Consortium for Translational Cancer Research (DKTK), Partner Site Freiburg, Freiburg, Germany, ³Dept. of Anesthesiology and Critical Care, Medical Center University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany

Dynamic ¹⁷O-MRI with inhalation of isotope-enriched ¹⁷O₂ is capable of directly quantifying the cerebral metabolic rate of oxygen consumption (CMRO₂). In this work, we investigated oxygen metabolism in brain subcortical structures including thalamus, dorsal striatum, caudate nucleus and insula cortex. The determined CMRO₂ values in these areas were compared with literature values obtained by PET studies. Our results show the feasibility of measuring local CMRO₂ in brain subcortical structures using ¹⁷O-MRI at 3T.

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