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Abstract #1795

Sodium TQ signal of amino acids and α-lactalbumin in comparison to bovine serum albumin

Dennis Kleimaier1, Simon Reichert1, Victor Schepkin2, and Lothar R. Schad1
1Computer Assisted Clinical Medicine, Heidelberg University, Mannheim, Germany, 2National High Magnetic Field Laboratory, Florida State University, Tallahassee, FL, United States

This study demonstrates that amino acids and the protein α-LA do not yield a sodium TQ signal. Despite a significant reduction in sodium relaxation times, a sodium TQ signal was not observed for the amino acids glutamic acid, arginine, and lysine, as well as for the small sized protein α-LA up to their highest concentration dissolvable in water. In contrast, a BSA concentration of 3% w/v was already sufficient for the creation of a sodium TQ signal. Consequently, in vivo small molecules can only contribute to a reduction in the MR relaxation times without a detectable sodium TQ signal.

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