Abstract #1794

Evaluation of different References for the Quantification of Tissue Sodium Concentration in Patients with ischemic Stroke

Anne Adlung¹, Sherif Mohamed², Nadia Karina Paschke¹, Mara Berger¹, Melina Samartzi³, Marc Fatar³, Achim Gass⁴, Eva Neumaier Probst², and Lothar Rudi Schad¹

¹Computer Assisted Clinical Medicine, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany, ²Department of Neuroradiology, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany, ³Department of Neurology, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany, ⁴Heidelberg University, Mannheim, Germany

²³Na MRI is an indicator for cell viability and quantification provides the tissue sodium concentration (TSC). Aim of this study is to evaluate the reliability of cerebrospinal fluid (CSF) and vitreous humor (VH) as internal references for TSC quantification. Data of 49 patients with ischemic stroke was included for TSC quantification which was performed based on signal intensity within external references, CSF and VH. TSC of healthy tissue was significantly lower compared to pathological tissue. Results showed a high similarity between the three quantification methods. Internal references would simplify ²³Na MRI measurements and thus its clinical establishment.

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