Abstract #1793

23Na MRI of mild traumatic brain injury: linear regression analysis reveals decreased total sodium concentration

TERESA GERHALTER¹, Anna M. Chen¹, Seena Dehkharghani¹, Rosermary Peralta¹, Fatemeh Adlparvar¹, James S. Babb¹, Tamara Bushnik², Jonathan M. Silver³, Brian S. Im², Stephen P. Wall⁴, Ryan Brown¹, Guillaume Madelin¹, and Ivan Kirov¹

¹Center for Biomedical Imaging, Department of Radiology, New York University Grossman School of Medicine, NEW YORK, NY, United States, ²Department of Rehabilitation Medicine, New York University Grossman School of Medicine, NEW YORK, NY, United States, ³Department of Psychiatry, New York University Grossman School of Medicine, NEW YORK, NY, United States, ⁴Ronald O. Perelman Department of Emergency Medicine, New York University Grossman School of Medicine, NEW YORK, NY, United States

In this quantitative sodium MRI study, 27 mild traumatic brain injury (mTBI) and 19 controls were scanned at 3 T. Linear regression analysis was used to measure total sodium concentrations (TSC) in global grey and white matter. We found statistically significant lower global grey and white matter TSC in mTBI patients compared to controls. This suggests that sodium imbalances in TBI, well-recognized from basic research, can be detectable non-invasively, are widespread over the entire brain, and are present even when the injury is clinically mild.

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