Abstract #1800

Dynamic Oxygen-17 MRI with Model-Based Approach for Mapping Cerebral Metabolic Rate of Oxygen in Mouse Brain at 9.4 T

Yuning Gu¹, Huiyun Gao², Kihwan Kim¹, Yunmei Wang², and Xin Yu^1,3

¹Biomedical Engineering, Case Western Reserve University, Cleveland, OH, United States, ²Medicine, Case Western Reserve University, Cleveland, OH, United States, ³Radiology, Case Western Reserve University, Cleveland, OH, United States

An oxygen-17 (¹⁷O) MRI method combining 3D golden-means-based radial sampling with model-based parameter mapping was developed for non-invasive measurement of cerebral metabolic rate of oxygen (CMRO₂) after inhalation of ¹⁷O-oxygen (¹⁷O₂). The method enabled quantification of CMRO₂ in post-stroke mouse brain with a nominal isotropic spatial resolution of 1.6 mm. CMRO₂ was 1.5 to 2.5 μmol/g/min in the normal tissue, and was ~1 μmol/g/min in the infarct region.

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