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Abstract #1801

Liver parenchymal change after stereotactic radiotherapy for hepatocellular carcinoma using DWI  and  MRE

Yoshie Omiya1, Utaroh Motosugi2, Hiroyuki Morisaka1, and Hiroshi Onishi1
1University of Yamanashi, Yamanashi, Japan, 2Kofu-Kyoritsu Hospital, Yamanashi, Japan

Stereotactic body radiotherapy (SBRT) is a treatment option for patients with hepatocellular carcinoma (HCC). It has been difficult to know radiation induced liver damage by SBRT using conventional imaging modalities. In this study, we evaluated the liver parenchymal changes after SBRT using two quantitative MR imaging; stiffness measurement with MR Elastography(MRE) and the apparent diffusion coefficient (ADC) values with DWI.Liver stiffness and ADC values were significantly elevated in both the liver parenchymal areas receiving large radiation dose (>30Gy) and small radiation dose(<15Gy). Liver stiffness and ADC values might be able to catch the substantial liver parenchymal changes after SBRT.

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