Abstract #1802

Deuterium Metabolic Imaging of the human brain at 9.4 T: Coil design and dynamic glucose uptake

Loreen Ruhm^1,2, Nikolai Avdievitch¹, Theresia Ziegs^1,2, Armin M. Nagel^3,4, Henk M. De Feyter⁵, Robin A. de Graaf⁵, and Anke Henning^1,6

¹High-Field MR Center, Max Planck Institute for Biological Cybernetics, Tuebingen, Germany, ²IMPRS for Cognitive and Systems Neuroscience, Eberhard-Karls University, Tuebingen, Germany, ³Institute of Radiology, University Hospital Erlangen, Erlangen, Germany, ⁴Division of Medical Physics in Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany, ⁵Radiology and Biomedical Imaging, Yale University, New Haven, CT, United States, ⁶Advanced Imaging Research Center, UT Southwestern Medical Center, Dallas, TX, United States

DMI (Deuterium Metabolic Imaging) is a technique that enables the investigation of metabolic turnover rates along predefined pathways non-invasively. In this work, we present first DMI data from the human brain at B₀ = 9.4T and an investigation of the dynamic glucose uptake in different areas of the human head for healthy volunteers and after the oral administration of [6,6’-²H]-glucose. We present a dedicated phased array coil design and ²H MRSI data with high spatial resolution for water, glucose, Glx and lipid/lactate. Finally, we compare the uptake curves for different regions in the human head.

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