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Abstract #1802

Deuterium Metabolic Imaging of the human brain at 9.4 T: Coil design and dynamic glucose uptake

Loreen Ruhm1,2, Nikolai Avdievitch1, Theresia Ziegs1,2, Armin M. Nagel3,4, Henk M. De Feyter5, Robin A. de Graaf5, and Anke Henning1,6
1High-Field MR Center, Max Planck Institute for Biological Cybernetics, Tuebingen, Germany, 2IMPRS for Cognitive and Systems Neuroscience, Eberhard-Karls University, Tuebingen, Germany, 3Institute of Radiology, University Hospital Erlangen, Erlangen, Germany, 4Division of Medical Physics in Radiology, German Cancer Research Center (DKFZ), Heidelberg, Germany, 5Radiology and Biomedical Imaging, Yale University, New Haven, CT, United States, 6Advanced Imaging Research Center, UT Southwestern Medical Center, Dallas, TX, United States

DMI (Deuterium Metabolic Imaging) is a technique that enables the investigation of metabolic turnover rates along predefined pathways non-invasively. In this work, we present first DMI data from the human brain at B0 = 9.4T and an investigation of the dynamic glucose uptake in different areas of the human head for healthy volunteers and after the oral administration of [6,6’-2H]-glucose. We present a dedicated phased array coil design and 2H MRSI data with high spatial resolution for water, glucose, Glx and lipid/lactate. Finally, we compare the uptake curves for different regions in the human head.

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