Abstract #1820

MR detection of gas microbubbles via hyperCEST: a path toward a dual modality contrast agent

Christian T McHugh¹, Phillip G Durham², Michele Kelley¹, Paul A Dayton³, and Rosa T Branca¹

¹Physics & Astronomy, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States, ²Pharmacoengineering and Molecular Pharmaceutics, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States, ³Biomedical Engineering, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States

Gas microbubbles are capable of providing both ultrasound and MRI image contrast, but at differing concentration levels. In order for gas microbubbles to be detected by MRI at the clinical ultrasound dose, a more sensitive detection scheme must be employed. Here we demonstrate that hyperCEST is capable of detecting gas microbubbles at clinically relevant US concentrations, thus enabling their use as a dual modality contrast agent.

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