Identification and quantification of imaging biomarkers sensitive to iron are important in understanding neurodegenerative disorders and aging. In this study, we introduce a microstructural parameter, $$$\delta\Omega^{2}$$$, the Larmor frequency variance, measured from the curvature in the logarithm of the signal from a 3D multiecho gradient echo sequence. Non-monoexponential relaxation originates from magnetic field perturbations due to the presence of mesoscopic susceptibility sources such as cellular-level iron. Our results in 26 healthy subjects show a strong linear correlation between $$$\delta\Omega^{2}$$$ and published values for iron concentration in deep gray matter regions, suggesting its potential as an imaging biomarker for iron.
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