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Abstract #1831

Pyruvate Infusion Rates for Hyperpolarized Metabolite Imaging of Human Heart

Jeffry R. Alger1,2,3,4, Jae Mo Park1, Junjie Ma1, Mahitha Roy1, Crystal Harrison1, James Ratnakar1, Albert Chen5, Galen Reed6, A. Dean Sherry1,7, Vlad Zaha1, and Craig R. Malloy1,8
1Advanced Imaging Research Center, University of Texas Southwestern Medical Center, Dallas, TX, United States, 2Neurology, University of California, Los Angeles, Los Angeles, CA, United States, 3NeuroSpectroScopics LLC, Sherman Oaks, CA, United States, 4Hura Imaging Inc, Los Angeles, CA, United States, 5GE Healthcare, Toronto, ON, Canada, 6GE Healthcare, Dallas, TX, United States, 7Chemistry, University of Texas at Dallas, Richardson, TX, United States, 8Cardiology, Veterans Affairs North Texas Healthcare System, Dallas, TX, United States

MRI/MRS metabolic tracing in human heart with hyperpolarized 13C-enriched pyruvate is feasible, but there remains a need to define the optimal infusion timing that accommodates both short polarization lifetime and subject comfort. Typical studies have used a 5.0 cm3/sec pyruvate infusion rate. We hypothesized that slower infusion is feasible because of the in vitro versus intravascular T1 difference and because vascular properties limit the rate of pyruvate delivery from the infusion site to the heart. Vascular dynamic simulations and preliminary human investigations suggest that a 2.0 cm3/sec pyruvate infusion rate be effectively used.

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