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Abstract #1850

Blood flow measurements in diabetic kidney disease: A comparison of phase contrast, arterial spin labelling and dynamic contrast enhanced MRI

Bashair Alhummiany1, David Shelley1,2, Margaret Saysell1,2, Maria-Alexandra Olaru3, Bernd Kühn3, David L. Buckley1, Julie Bailey2, Michael Mansfield2, Steven Sourbron4, and Kanishka Sharma4
1Department of Biomedical Imaging Sciences, University of Leeds, Leeds, United Kingdom, 2Leeds Teaching Hospitals, NHS Trust, Leeds, United Kingdom, 3Siemens Healthcare GmbH, Erlangen, Germany, 4Department of Imaging, Infection, Immunity and Cardiovascular Disease, The University of Sheffield, Sheffield, United Kingdom

Kidney perfusion can be measured using DCE or ASL, but clinical confidence in the assays is undermined by the large variability in published values. In this study, an intra-subject comparison was performed of DCE and ASL against phase-contrast RBF in 25 patients with diabetic kidney disease. Results show that the three techniques agree well on average, but pairwise agreement on the single-subject level remains poor. ASL agreed better with PC than DCE, but the difference was driven by a single DCE outlier. While RBF is a useful biomarker for studies at population level, individual patient management will require further optimization.

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