Abstract #1861

Perfusion mapping with sinusoidal CO2 respiratory challenge

Chau Vu¹, Jian Shen¹, Matthew Borzage², Soyoung Choi³, and John Wood⁴

¹Biomedical Engineering, University of Southern California, Los Angeles, CA, United States, ²Fetal and Neonatal Institute, Children's Hospital Los Angeles, Los Angeles, CA, United States, ³Neuroscience Graduate Program, University of Southern California, Los Angeles, CA, United States, ⁴Pediatrics and Radiology, Children's Hospital Los Angeles, Los Angeles, CA, United States

Dynamic susceptibility contrast MRI is a popular perfusion technique that requires the use of intravenous exogenous contrast. To avoid gadolinium injection, this study proposed a perfusion MRI method based on a CO₂ respiratory challenge, which delivers a sinusoidally-modulated CO₂ stimulus. We evaluated this technique at two different stimulus amplitudes and reported cerebral blood flow (CBF), cerebral blood volume (CBV) and transit time (TT) within the acceptable range of the previous literature.

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