Abstract #1862

Evidence for a sustained cerebrovascular response following motor practice

Eleonora Patitucci¹, Michael Germuska¹, James Kolasinski¹, Valentina Tomassini^1,2,3, and Richard G Wise^1,2

¹CUBRIC, Cardiff University, Cardiff, United Kingdom, ²Institute for Advanced Biomedical Technologies (ITAB), Department of Neurosciences, Imaging and Clinical Sciences, University of Chieti-Pescara, Chieti, Italy, ³MS Centre, Neurology Unit, SS. Annunziata University Hospital, Chieti, Italy

Functional MRI can detect modifications in the brain’s resting state with learning-related behavioural improvements. However, the impact of learning on local cerebral blood flow after task execution remains unclear. Here we investigate changes in CBF after the execution of a motor task and demonstrate a sustained increase in resting CBF that is localised in regions relevant for the learning of the task. Our results show that learning induces sustained changes of local cerebral blood flow (over a timescale of minutes).

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