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Abstract #1863

Effect of subject-specific T1 values for arterial spin labelling on cerebral blood flow in mild stroke patients

Michael S Stringer1,2, Cameron Manning1,2, Una Clancy1,2, Alasdair Morgan1,2, Zahra Shirzadi3,4, Francesca M Chappell1,2, Dany Jaime Garcia1,2, Angela CC Jochems1,2, Maria Valdes-Hernandez1,2, Stewart Wiseman1,2, Eleni Sakka1,2, Gordon W Blair1,2, Rosalind Brown1,2, Bradley MacIntosh3,4, Ian Marshall1,2, Fergus Doubal1,2, and Joanna M Wardlaw1,2
1Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, United Kingdom, 2UK DRI at the University of Edinburgh, Edinburgh, United Kingdom, 3Hurvitz Brain Sciences Research Program, Sunnybrook Health Sciences Centre, Toronto, ON, Canada, 4Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada

Accurate cerebral blood flow (CBF) quantification using arterial spin labelling (ASL) relies on physiological and MR parameters. Longitudinal relaxation time (T1) of blood, which depends on haematocrit, can be a factor in some patient groups. We determined subject-specific T1 using the DESPOT-1 HIFI method in a mild stroke cohort, calculating CBF using nominal and subject-specific values. CBF calculated with subject-specific T1 values was lower in grey and higher in white matter, though there was not a proportional bias. CBF was lower in patients with higher disease burden. Subject-specific T1 values can reduce variance, potentially improving CBF quantification in clinical ASL.

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