Abstract #1863

Effect of subject-specific T1 values for arterial spin labelling on cerebral blood flow in mild stroke patients

Michael S Stringer^1,2, Cameron Manning^1,2, Una Clancy^1,2, Alasdair Morgan^1,2, Zahra Shirzadi^3,4, Francesca M Chappell^1,2, Dany Jaime Garcia^1,2, Angela CC Jochems^1,2, Maria Valdes-Hernandez^1,2, Stewart Wiseman^1,2, Eleni Sakka^1,2, Gordon W Blair^1,2, Rosalind Brown^1,2, Bradley MacIntosh^3,4, Ian Marshall^1,2, Fergus Doubal^1,2, and Joanna M Wardlaw^1,2

¹Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, United Kingdom, ²UK DRI at the University of Edinburgh, Edinburgh, United Kingdom, ³Hurvitz Brain Sciences Research Program, Sunnybrook Health Sciences Centre, Toronto, ON, Canada, ⁴Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada

Accurate cerebral blood flow (CBF) quantification using arterial spin labelling (ASL) relies on physiological and MR parameters. Longitudinal relaxation time (T₁) of blood, which depends on haematocrit, can be a factor in some patient groups. We determined subject-specific T₁ using the DESPOT-1 HIFI method in a mild stroke cohort, calculating CBF using nominal and subject-specific values. CBF calculated with subject-specific T₁ values was lower in grey and higher in white matter, though there was not a proportional bias. CBF was lower in patients with higher disease burden. Subject-specific T₁ values can reduce variance, potentially improving CBF quantification in clinical ASL.

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